Orain, David: search on Z-Library

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1

From Solution-Phase Studies to Solid-Phase Synthesis: A New Indole Based Scaffold for Combinatorial Chemistry

Orain, David, Koch, Guido, Giger, Rudolf

Journal:

CHIMIA International Journal for Chemistry

Year:

2003

Language:

english

File:

PDF, 196 KB

english, 2003

2

Linkers and Cleavage Strategies in Solid-Phase Organic Synthesis and Combinatorial Chemistry

Guillier, Fabrice, Orain, David, Bradley, Mark

Journal:

Chemical Reviews

Year:

2000

Language:

english

File:

PDF, 1.11 MB

english, 2000

3

Protecting Groups in Solid-Phase Organic Synthesis

Orain, David, Ellard, John, Bradley, Mark

Journal:

Journal of Combinatorial Chemistry

Year:

2002

Language:

english

File:

PDF, 202 KB

english, 2002

4

Optimizing a weakly binding fragment into a potent RORγt inverse agonist with efficacy in an in vivo inflammation model

Carcache, David, Vulpetti, Anna, Kallen, Joerg, Mattes, Henri, Orain, David, Stringer, Rowan, Vangrevelinghe, Eric, Wolf, Romain M, Kaupmann, Klemens, Ottl, Johannes, Dawson King, Janet, Cooke, Nigel

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.88 MB

english, 2018

5

Identification of Grossing Criteria for Intraoperative Evaluation by Frozen Section of Lung Cancer Resection Margins

Gagné, Andréanne, Racine, Étienne, Orain, Michèle, Meziou, Salma, Simard, Serge, Couture, Christian, Pagé, Sylvain, Trahan, Sylvain, Ugalde, Paula, Lacasse, Yves, Joubert, David, Joubert, Philippe

Journal:

American Journal of Surgical Pathology

Year:

2018

Language:

english

File:

PDF, 135 KB

english, 2018

6

Synthesis of Orthogonally Protected 2,6-Diazaspiro[3.5]nonane and 2,6-Diazaspiro[3.4]octane Analogues as Versatile Building Blocks in Medicinal Chemistry

Orain, David, Hintermann, Samuel, Pudelko, Maciej, Carballa, Diego, Jedrzejczak, Anna

Journal:

Year:

2015

Language:

english

File:

PDF, 156 KB

english, 2015

7

Cover Picture: Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist (ChemMedChem 3/2017)

Orain, David, Tasdelen, Engin, Haessig, Samuel, Koller, Manuel, Picard, Anne, Dubois, Celine, Lingenhoehl, Kurt, Desrayaud, Sandrine, Floersheim, Phillip, Carcache, David, Urwyler, Stephan, Kallen, Jo

Journal:

Year:

2017

File:

PDF, 481 KB

2017

8

ChemInform Abstract: Piperidyl Amides as Novel, Potent and Orally Active mGlu5 Receptor Antagonists with Anxiolytic-Like Activity.

Carsten Spanka, Ralf Glatthar, Sandrine Desrayaud, Markus Fendt, David Orain, Thomas Troxler, Ivo Vranesic

Journal:

Year:

2010

File:

PDF, 18 KB

2010

9

Cover Picture: BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution (ChemMedChem 4/2011)

Dr. Emmanuelle Briard, Dr. David Orain, Dr. Christian Beerli, Dr. Andreas Billich, Dr. Markus Streiff, Dr. Marc Bigaud, Dr. Yves P. Auberson

Journal:

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

10

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists

David Orain, Silvio Ofner, Manuel Koller, David A. Carcache, Wolfgang Froestl, Hans Allgeier, Vittorio Rasetti, Joachim Nozulak, Henri Mattes, Nicolas Soldermann, Philipp Floersheim, Sandrine Desrayau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 510 KB

english, 2012

11

A Novel Intramolecular Palladium-Mediated Cyclization for the Synthesis of Substituted 2-(Aryl- or Benzylamino)-4 H -1,3-Benzothiazines

Orain, David, Blumstein, Anne-Catherine, Tasdelen, Engin, Haessig, Samuel

Journal:

Year:

2008

Language:

english

File:

PDF, 85 KB

english, 2008

12

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis

Velcicky, Juraj, Miltz, Wolfgang, Oberhauser, Berndt, Orain, David, Vaupel, Andrea, Weigand, Klaus, Dawson King, Janet, Littlewood-Evans, Amanda, Nash, Mark, Feifel, Roland, Loetscher, Pius

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

13

Efficient Solution and Solid-Phase Synthesis of a 3,9-Diazabicyclo[3.3.1]non-6-en-2-one Scaffold.

David Orain, Riccardo Canova, Michele Dattilo, Edgar Kloeppner, Regis Denay, Guido Koch, Rudolf Giger

Journal:

Year:

2002

File:

PDF, 31 KB

2002

14

Concise Synthesis of 1 H -Pyrazin-2-ones and 2-Aminopyrazines

Adam, Isabelle, Orain, David, Meier, Peter

Journal:

Year:

2004

Language:

english

File:

PDF, 111 KB

english, 2004

15

Concise Synthesis of 1H-Pyrazin-2-ones and 2-Aminopyrazines.

Isabelle Adam, David Orain, Peter Meier

Journal:

Year:

2005

File:

PDF, 19 KB

2005

16

Comprehensive assessment of PD-L1 immunohistochemistry on paired tissue and cytology specimens from non-small cell lung cancer

GagnÃ©, AndrÃ©anne, Orain, MichÃ¨le, Ionescu, Diana, Tsao, Ming-Sound, Joubert, David, Joubert, Philippe

Journal:

Year:

2020

File:

PDF, 1.69 MB

2020

17

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity

Carsten Spanka, Ralf Glatthar, Sandrine Desrayaud, Markus Fendt, David Orain, Thomas Troxler, Ivo Vranesic

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.80 MB

english, 2010

18

A safety-catch linker for amine release under biologically compatible conditions

David Orain, Mark Bradley

Journal:

Molecular Diversity

Year:

2000

Language:

english

File:

PDF, 130 KB

english, 2000

19

Inside Cover: Design and Synthesis of Selective and Potent Orally Active S1P5 Agonists (ChemMedChem 10/2010)

Dr. Henri Mattes, Prof. Dr. Kumlesh Kumar Dev, Dr. Rochdi Bouhelal, Dr. Carmen Barske, Dr. Fabrizio Gasparini, Dr. Danilo Guerini, Dr. Anis Khusro Mir, Dr. David Orain, Maribel Osinde, Anne Picard, Ce

Journal:

Year:

2010

Language:

english

File:

PDF, 518 KB

english, 2010

20

Fear-reducing effects of intra-amygdala neuropeptide Y infusion in animal models of conditioned fear: an NPY Y1 receptor independent effect

Markus Fendt, Hugo Bürki, Stefan Imobersteg, Kurt Lingenhöhl, Kevin H. McAllister, David Orain, Doncho P. Uzunov, Frederique Chaperon

Journal:

Psychopharmacology

Year:

2009

Language:

english

File:

PDF, 610 KB

english, 2009

21

Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists

Koller, Manuel, Carcache, David A., Orain, David, Ertl, Peter, Behnke, Dirk, Desrayaud, Sandrine, Laue, Grit, Vranesic, Ivo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.04 MB

english, 2012

22

Synthesis of Functionalized Deuterioallylic Compounds

Orain, David, Guillemin, Jean-Claude

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 63 KB

english, 1999

23

Palaeoenvironments of early hominins in temperate and Mediterranean Eurasia: new palaeobotanical data from Palaeolithic key-sites and synchronous natural sequences

Erwan Messager, Vincent Lebreton, Laurent Marquer, Elda Russo-Ermolli, Ronan Orain, Josette Renault-Miskovsky, David Lordkipanidze, Jackie Despriée, Carlo Peretto, Marta Arzarello

Journal:

Quaternary Science Reviews

Year:

2011

Language:

english

File:

PDF, 825 KB

english, 2011

24

Corrigendum: Design and Synthesis of Selective and Potent Orally Active S1P5 Agonists

Dr. Henri Mattes, Prof. Dr. Kumlesh Kumar Dev, Dr. Rochdi Bouhelal, Dr. Carmen Barske, Dr. Fabrizio Gasparini, Dr. Danilo Guerini, Dr. Anis Khusro Mir, Dr. David Orain, Maribel Osinde, Anne Picard, Ce

Journal:

Year:

2010

File:

PDF, 57 KB

2010

25

Solid phase synthesis of trypanothione reductase inhibitors—towards single bead screening

David Orain, Mark Bradley

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 80 KB

english, 2001

26

Efficient Solution and Solid-Phase Synthesis of a 3,9-Diazabicyclo[3.3.1]non-6-en-2-one Scaffold

Orain, David, Canova, Riccardo, Dattilo, Michele, Klöppner, Edgar, Denay, Régis, Koch, Guido, Giger, Rudolf

Journal:

Year:

2002

Language:

english

File:

PDF, 154 KB

english, 2002

27

From Solution-Phase Studies to Solid-Phase Synthesis: A New Indole-Based Scaffold for Combinatorial Chemistry

David Orain, Guido Koch, Rudolf Giger

Journal:

Year:

2004

File:

PDF, 56 KB

2004

28

Linkers and Cleavage Strategies in Solid-Phase Organic Synthesis and Combinatorial Chemistry. (Chem. Rev. 2000, 100, 2091. Published on the Web May 6, 2000).

Guillier, Fabrice, Orain, David, Bradley, Mark

Journal:

Chemical Reviews

Year:

2000

File:

PDF, 10 KB

2000

29

Solid-phase template-directed synthesis of a [2]rotaxane using a solid-phase stopper

Bravo, José A., Orain, David, Bradley, Mark

Journal:

Chemical Communications

Year:

2002

Language:

english

File:

PDF, 333 KB

english, 2002

30

AMPA Receptor Antagonists: Potential Therapeutic Applications

Mattes, Henri, Lingenhoehl, Kurt, Kalkman, Hans, Auberson, Yves, Renaud, Johanne, Schmutz, Markus, Orain, David

Journal:

Recent Patents on CNS Drug Discovery

Year:

2006

Language:

english

File:

PDF, 84 KB

english, 2006

31

Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

Ecoeur, Florence, Weiss, Jessica, Kaupmann, Klemens, Hintermann, Samuel, Orain, David, Guntermann, Christine

Journal:

Frontiers in Immunology

Year:

2019

Language:

english

File:

PDF, 2.40 MB

english, 2019

32

Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist

Orain, David, Tasdelen, Engin, Haessig, Samuel, Koller, Manuel, Picard, Anne, Dubois, Celine, Lingenhoehl, Kurt, Desrayaud, Sandrine, Floersheim, Phillip, Carcache, David, Urwyler, Stephan, Kallen, Jo

Journal:

Year:

2016

Language:

english

File:

PDF, 564 KB

english, 2016

33

Impact of Specimen Characteristics on PD-L1 Testing in Non–Small Cell Lung Cancer: Validation of the IASLC PD-L1 Testing Recommendations

Gagné, Andréanne, Wang, Emily, Bastien, Nathalie, Orain, Michèle, Desmeules, Patrice, Pagé, Sylvain, Trahan, Sylvain, Couture, Christian, Joubert, David, Joubert, Philippe

Journal:

Journal of Thoracic Oncology

Year:

2019

Language:

english

File:

PDF, 340 KB

english, 2019

34

Synthesis of Two New Azabicyclophosphinic Acids as Constrained Analogues of TPMPA

Orain, David, Mattes, Henri

Journal:

Year:

2005

Language:

english

File:

PDF, 54 KB

english, 2005

35

Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

Ecoeur, Florence, Weiss, Jessica, Kaupmann, Klemens, Hintermann, Samuel, Orain, David, Guntermann, Christine

Journal:

Frontiers in Immunology

Year:

2019

File:

PDF, 2.40 MB

2019

36

Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists

Hintermann, Samuel, Guntermann, Christine, Mattes, Henri, Carcache, David A., Wagner, Juergen, Vulpetti, Anna, Billich, Andreas, Dawson, Janet, Kaupmann, Klemens, Kallen, Joerg, Stringer, Rowan, Orain

Journal:

Year:

2016

Language:

english

File:

PDF, 974 KB

english, 2016

37

ChemInform Abstract: Linkers and Cleavage Strategies in Solid-Phase Organic Synthesis and Combinatorial Chemistry

Fabrice Guillier, David Orain, Mark Bradley

Journal:

Year:

2000

File:

PDF, 24 KB

2000

38

Mechanism of O2 diffusion and reduction in FeFe hydrogenases

Kubas, Adam, Orain, Christophe, De Sancho, David, Saujet, Laure, Sensi, Matteo, Gauquelin, Charles, Meynial-Salles, Isabelle, Soucaille, Philippe, Bottin, Hervé, Baffert, Carole, Fourmond, Vincent, Be

Journal:

Nature Chemistry

Year:

2016

Language:

english

File:

PDF, 2.79 MB

english, 2016

39

BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution

Dr. Emmanuelle Briard, Dr. David Orain, Dr. Christian Beerli, Dr. Andreas Billich, Dr. Markus Streiff, Dr. Marc Bigaud, Dr. Yves P. Auberson

Journal:

Year:

2011

Language:

english

File:

PDF, 452 KB

english, 2011

40

Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity

Manuel Koller, Kurt Lingenhoehl, Markus Schmutz, Ivan-Toma Vranesic, Joerg Kallen, Yves P. Auberson, David A. Carcache, Henri Mattes, Silvio Ofner, David Orain, Stephan Urwyler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 546 KB

english, 2011

41

Proteases and their inhibitors as prognostic factors for high-grade serous ovarian cancer

Trudel, Dominique, Avarvarei, Luminita-Mihaela, Orain, Michèle, Turcotte, Stéphane, Plante, Marie, Grégoire, Jean, Kappelhoff, Reinhild, Labbé, David P., Bachvarov, Dimcho, Têtu, Bernard, Overall, Chr

Journal:

Pathology - Research and Practice

Year:

2019

Language:

english

File:

PDF, 644 KB

english, 2019

42

ChemInform Abstract: Protecting Groups in Solid-Phase Organic Synthesis

David Orain, John Ellard, Mark Bradley

Journal:

Year:

2002

File:

PDF, 23 KB

2002

43

Synthesis of imidazole phosphinic acids as I4AA analogues

David Orain, Henri Mattes

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 90 KB

english, 2006

44

Structural states of RORγt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds

Kallen, Joerg, Izaac, Aude, Be, Celine, Arista, Luca, Orain, David, Kaupmann, Klemens, Guntermann, Christine, Hoegenauer, Klemens, Hintermann, Samuel

Journal:

Year:

2017

Language:

english

File:

PDF, 2.29 MB

english, 2017

45

Stereoselective Transformation of Indole Diazabicyclo[3.2.2]nonedione to Azepinoindole

Orain, David, Denay, Régis, Koch, Guido, Giger, Rudolf

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 82 KB

english, 2002

46

Design and Synthesis of Selective and Potent Orally Active S1P5 Agonists

Dr. Henri Mattes, Prof. Dr. Kumlesh Kumar Dev, Dr. Rochdi Bouhelal, Dr. Carmen Barske, Dr. Fabrizio Gasparini, Dr. Danilo Guerini, Dr. Anis Khusro Mir, Dr. David Orain, Maribel Osinde, Anne Picard, Ce

Journal:

Year:

2010

Language:

english

File:

PDF, 455 KB

english, 2010

47

A study of the association between UGT1A1*28 variant allele of UGT1A1 gene and colonic phenotype of sporadic colorectal cancer

Anon, Benjamin, Perray, Clémence, Regnault, David, Caulet, Morgane, Orain, Isabelle, Godart, Bruno, Pages, Jean-Christophe, Tallet, Anne, Ouaissi, Mehdi, Guyetant, Serge, Barin-le Guellec, Chantal, Le

Journal:

Digestive and Liver Disease

Year:

2018

Language:

english

File:

PDF, 542 KB

english, 2018

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